White Rose Way has been blocked after the collision shortly after noon earlier today.
Police have stated that three people have been taken to hospital after the collision, one of those involved is in a serious condition.
A South Yorkshire police spokesman said: “Police were called today at 12.11 to report a traffic collision on the White Rose Way near Lakeside Village in Doncaster.
“It is reported that two cars were involved in the collision and three people including the drivers of both vehicles and a passenger have been brought to the hospital by ambulance.
“One person is in a serious condition.
“Police remain at the facility and the White Rose Way section between the Middle Bank roundabout and the Wilmington Drive intersection remains closed. Investigations are underway.”